High-Purity Cosmetic grade Sodium Polyglutamate and Calcium Polyglutamate

When it comes to the premium skincare, the formulators need ingredients that deliver deep hydration, mildness, and sustainability. Cosmetic γ polyglutamic acid (γ-PGA), available as cosmetic-grade sodium polyglutamate and cosmetic-grade calcium polyglutamate, meets these demands. Produced by Bacillus subtilis fermentation, this biopolymer offers up to 5,000× its weight in water-holding capacity. As a cosmetic poly γ glutamic acid factory, we supply high purity γ-PGA for premium skincare moisturization in multiple molecular weights.

Why γ-PGA Is Redefining Cosmetic Moisturization

γ-PGA is water-soluble, biodegradable, non-immunogenic, and rich in carboxyl and hydroxyl groups. It attracts and retains moisture, forms a breathable film, and helps accumulate Natural Moisturizing Factors (NMF). It also inhibits hyaluronidase, preserving natural hyaluronic acid, and supports fibroblast activity for firmer skin.

Sodium Polyglutamate: Lightweight, High-Performance Hydration

Highly moisturizing sodium polyglutamate is the most widely used cosmetic form. It is lightweight, non-sticky, and ideal for serums, essences, gels, creams, and masks. It delivers hydration comparable to or better than hyaluronic acid and glycerol while reducing transepidermal water loss. It supports long-term moisture retention and works well with other actives.

Key benefits of Sodium Polyglutamate:

1. Ultra-high hydration capacity, absorbing up to 5,000× its weight in water

2. Non-sticky, breathable film formation — ideal for leave-on formulations

3. Promotes NMF accumulation for long-term moisture retention

4. Inhibits hyaluronidase, preserving skin’s natural HA

5. Boosts collagen synthesis and skin elasticity

6. Excellent compatibility with a wide range of cosmetic actives

Ideal applications:

l Daily moisturizers & creams

l Hydrating serums & ampoules

l Sheet masks & hydrogels

l Essences & toners

l Eye creams & spot treatments

Calcium Polyglutamate: Gentle Barrier Repair for Sensitive Skin

Cosmetic-grade calcium polyglutamate is designed for sensitive skin and barrier repair. Calcium ions support epidermal barrier integrity and regeneration. It can provide more than 10× the moisturizing power of hyaluronic acid and is clinically useful at 0.5%–1.0% for barrier repair. It is gentle, stable, and suitable for sunscreens, primers, night creams, and post-procedure care.

Key benefits of Calcium Polyglutamate:

1. Gentle, stable, and highly skin-compatible

2. Superior moisturizing power — over 10× that of HA

3. Supports calcium-mediated barrier repair and regeneration

4. Anti-inflammatory properties suitable for reactive skin

5. Creates a micro-thin, breathable moisture shield

6. Non-irritating and suitable for long-term leave-on use

Ideal applications:

l Sensitive skin formulations

l Barrier repair creams

l Sunscreens & primers

l Night creams & sleeping packs

l Post-procedure skincare

l Atopic-prone skin care

γ-PGA vs. Hyaluronic Acid: A High-Performance Alternative

The comparison between γ-PGA and hyaluronic acid is one of the most discussed topics in modern cosmetic science. Both are excellent moisturizers, but they work through different mechanisms and at different depths.

As noted in recent research, γ-PGA “offers new opportunities to enhance hydration beyond what traditional hyaluronic acid can achieve”. High-molecular-weight γ-PGA delivers immediate and long-lasting surface hydration, while lower-molecular-weight fractions penetrate deeper to support skin longevity.

Multi-Molecular Weight γ-PGA: Precision Hydration for Every Layer

Multi-molecular weight γ-PGA allows precision hydration. High-molecular-weight fractions form a surface film for immediate moisture and reduced TEWL. Low-molecular-weight oligomers penetrate deeper for lasting hydration, antioxidant support, and skin longevity. Blending fractions tailors sensory feel and performance for different product types.

Clean Beauty & Sustainability: A Naturally Aligned Ingredient

As a sustainable mild moisturizer for clean beauty formulations, γ-PGA is non-animal, fermentation-derived, water-soluble, and fully biodegradable. It avoids solvent and animal-derived concerns linked to some hyaluronic acid production. It fits clean beauty programs and premium skincare trends.

Product Specifications

Product forms available:

Sodium Polyglutamate — Highly moisturizing, water-soluble, lightweight

Calcium Polyglutamate — Gentle, stable, skin-friendly, barrier-supportive

Comprehensive Application Guide

Recommended usage levels are generally between 0.05% and 1.00% in cosmetic formulations. Calcium Polyglutamate requires a minimum of 0.5% for functional barrier repair benefits.

Safety Profile

γ-PGA and its salts are hypoallergenic, non-comedogenic, and well tolerated. They are not known to irritate skin or cause sensitization. Typical cosmetic concentrations are safe for sensitive skin and long-term leave-on use.

Why Choose Our Cosmetic-Grade γ-PGA?

As a dedicated cosmetic poly γ-glutamic acid factory, we offer:

1. High-purity, cosmetic-grade γ-PGA with ≥92% assay (HPLC)

2. Multi-molecular weight options for precise formulation control

3. Sustainable, clean-beauty compliant production — non-animal, natto-fermented

4. Two salt forms — Sodium and Calcium — for diverse formulation needs

5. Technical support & OEM/ODM services for formulation development

6. Reliable global supply with consistent quality and documentation

7. COSMOS-certified options available for organic-compliant formulations

Our fermentation platform is built on Bacillus subtilis natto strains, ensuring consistent molecular weight distribution, high purity, and batch-to-batch reproducibility.

Request a Sample

Contact us for samples, technical data sheets, or formulation support for cosmetic-grade sodium polyglutamate and cosmetic-grade calcium polyglutamate. Our cosmetic poly γ glutamic acid factory can help you create high-performance, sustainable moisturizing products.